IAESTE Internships

Location

India

Internship type

ON-SITE

Reference number

IN-2025-A2614-JC

Students Requirements

General discipline

Biology
Biomedical Sciences

Completed Years of Study

1

Fields of Study

Languages

English Good (B1, B2)

Required Knowledge and Experience

-

Other Requirements

-

Work Details

Duration

8 - 24 Weeks

Within These Dates

25.01.2025 - 01.10.2025

Holidays

NONE

Work Environment

-

Gross pay

15000 INR / month

Working Hours

35.0 per week / 7.0 per day

Living Lodging

Type of Accommoditation

IAESTE

Cost of lodging

-

Cost of living

10000 INR / month

Work Offered

Additional Info

Work description

Project Title: Investigating Molecular Crowding and Drug Interactions on HPPD Activity: Implications for Tyrosinemia TherapyAim: The internship aims to explore the effects of molecular crowding and drug interactions on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) to understand tyrosinemia mechanisms and identify potential therapies. The focus is on how HPPD functions in crowded cellular environments, its activity levels, and the influence of drug interactions on its performance.Responsibilities:1. Analyze HPPD’s function and structure under crowded cellular conditions.2. Perform biochemical assays to measure and assess HPPD enzyme activity.3. Conduct structural biology experiments to determine HPPD's three-dimensional structure and modifications.4. Develop and refine computational models to simulate HPPD behavior under various conditions.5. Investigate drug interactions with HPPD and their effects on its function.6. Study the molecular mechanisms of tyrosinemia to elucidate its pathophysiology.7. Identify potential therapeutic targets for tyrosinemia treatment.8. Evaluate drug candidates for their ability to modulate HPPD activity.Outcomes:1. Understanding of molecular crowding effects on HPPD.2. Insights into tyrosinemia’s molecular mechanisms.3. Identification of new therapeutic targets.4. Experience in biochemical assays and structural biology.5. Skills in computational enzyme modeling.6. Knowledge of drug-enzyme interactions.7. Discovery of potential targeted therapies.8. Contribution to improved patient outcomes and publication-quality research findings.

Deadline

30.04.2025